Noida – April 19 2021. Jubilant Pharma Limited, a subsidiary of Jubilant Pharmova Limited, announces successful completion of safety and pharmacokinetic/absorption studies in animals and healthy human volunteers in India using a novel oral formulation of remdesivir against the commercially available injectable formulation of remdesivir.

Jubilant has sought authorization for additional studies for this novel oral formulation from the Drug Controller General of India (DCGI). Jubilant is hoping to provide an affordable, more convenient, easy-to-administer and potentially effective treatment option for COVID-19 patients. The proposed oral treatment is expected to be for 5 days, a duration similar to the injectable dosage form. Remdesivir is the first and the only anti-viral drug fully approved by the US FDA for the treatment of patients with COVID-19 requiring hospitalization.

This innovative formulation is likely to ease the capacity constraint that injectable formulation faces and ensure wider and timely availability for the patients of COVID-19. It is specifically designed to avoid hepatic metabolism which results in almost complete first-pass clearance/elimination of remdesivir when it is administered by the traditional oral route. The findings from both preclinical and human studies indicate that the drug is able to undergo absorption when administered using the novel oral formulation. The novel formulation was well tolerated by all the study subjects with no additional safety/ tolerability profile as compared to the injectable product.

In May 2020, Jubilant entered into a non-exclusive Licensing Agreement with Gilead Sciences, Inc. (NASDAQ: GILD) that granted it the right to register, manufacture and sell Gilead’s remdesivir in 127 countries including India. On July 20, 2020, Jubilant received approval from the Drug Controller General of India (DCGI) to manufacture and market the antiviral drug remdesivir (“JUBI-R”) for 100 mg/vial (lyophilized injection) for restricted emergency use in India for the treatment of severe COVID-19.

“We are pleased to announce the ongoing development of a novel formulation of Remdesivir to address the pandemic at this critical juncture. Once approved, this will not only provide a more convenient and easy-to-administer formulation but also support an increasing demand of COVID-19 treatments.” stated Mr. Shyam S. Bhartia, Chairman and Mr. Hari S. Bhartia, Co-Chairman and Managing Director, Jubilant Pharmova Limited.

About Jubilant Pharma Limited
Jubilant Pharma Limited (JPL), a company incorporated under the laws of Singapore and a wholly-owned subsidiary of Jubilant Pharmova Limited, is an integrated global pharmaceutical company engaged in manufacturing and supply of Radiopharmaceuticals, Allergy Therapy Products, Contract Manufacturing of Sterile Injectables and Non Sterile products, APIs, and Generics, through six US FDA approved manufacturing facilities in the US, Canada and India and a network of 49 radiopharmacies in the US. The Company has a team of around 5,200 multicultural people across the globe. It is well recognized as a 'Partner of Choice' by leading pharmaceutical companies globally.
For further information: Visit our website @ www.jubilantpharma.com

About Jubilant Pharmova Limited
Jubilant Pharmova Limited (formerly Jubilant Life Sciences Limited) is a company engaged in pharmaceuticals, contract research and development services and proprietary novel drugs businesses. Pharmaceuticals business through Jubilant Pharma Limited Singapore (JPL) is engaged in manufacturing and supply of Radiopharmaceuticals with a network of 49 radio-pharmacies in the US, Allergy Therapy Products, Contract Manufacturing of Sterile Injectibles and Non-sterile products, APIs and generics through six USFDA approved manufacturing facilities in the US, Canada and India. Jubilant Biosys Limited provides Contract Research and Development Services through two world class research centers in Bangalore and Noida in India. Jubilant Therapeutics is involved in Proprietary Novel Drugs business and is an innovative biopharmaceutical company developing breakthrough therapies in the area of oncology and auto-immune disorders. Jubilant Pharmova Limited has a team of around 5,800 multicultural people across the globe. The Company is well recognized as a ‘Partner of Choice’ by leading pharmaceuticals companies globally.

For further information: Visit our website @ www.jubilantpharmova.com

- JBI-778, abrain penetrant PRMT5 inhibitor demonstrated significant tumor growth inhibition in glioblastoma in addition to its activity against a number of other cancers–

- JBI-1527, a potent, selective oral inhibitor of PD-L1 exhibited T-cell restorationand immune-mediated tumor growth suppression -

- Data support the further development of PRMT5 inhibitor JBI-778 and PD-L1 inhibitor JBI-1527 for the treatment of unmet need in oncology

BEDMINSTER, New Jersey – April 10, 2021 – Jubilant Therapeutics Inc. , a biopharmaceutical company advancing oral, small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced that preclinical data fromtwo programs evaluating the company’s PRMT5 inhibitor and PD-L1 inhibitor as anti-cancer agents, will be presented today in a poster session at the American Association for Cancer Research (AACR) 2021 Annual Meeting taking place virtually from April 10-15, 2021.

“We are excited to announce theseimportant data from our PRMT5 and our PD-L1programs that show efficacy and tolerability in preclinical models,” said Syed Kazmi, President and Chief Executive Officer of Jubilant Therapeutics Inc. “Our oral PRMT5 inhibitor has good plasma and sustained brain exposure which results in strong target inhibition, tumor growth delay and survival advantage in both xenografts and orthotopic brain models. Our oral anti-PDL1 immunotherapeutics,with a shorter half-life,are an attractive alternative to current intravenous antibody therapies especially in the maintenance settingswith potential to limitimmune-mediated toxicities and side effects via innovative dosing approaches, while maintaining the class-based wide anti-tumor efficacyWe look forward to continuing our work on these programs as we see great potential for treating multiple cancers.”

A link to the e-posters, listed below, is available through the AACR website.

Title:Novel, small molecule PRMT5 inhibitors for treatment of cancer
Poster Number: 1128
Date and Time: April 10, 2021 at 8:30 a.m. Eastern Daylight Time (EDT)
Session Title: Epigenetic Targets
Presenter: Dhanalakshmi Sivanandhan, et al.

Title:Novel, small molecule inhibitors of PD-L1/PD-1 interaction
Poster Number: 1630
Date and Time: April 10, 2021 at 8:30 a.m. Eastern Daylight Time (EDT)
Session Title: Immune Checkpoints
Presenter: Dhanalakshmi Sivanandhan, et al.

PRMT5 over-expression, shown in several cancers including lymphoid, lung, breast, glioblastoma, gastric etc., is thought to be an important factor in its tumorigenicity due to its repressive function on tumor suppressor gene expression. Key highlights from an evaluation which examined the tumor growth inhibition of PRMT5 inhibitor JBI-778 in multiple cancer cell lines as well as glioblastoma, include the following:

• JBI-778 is a potent PRMT5 inhibitor that is selective against other PRMTs;
• JBI-778 showspotent anti-proliferative activity against a number of cancers;
• This oral small molecule demonstrated anti-tumor efficacy in a Mantle Cell lymphoma model with an ED50 of < 10 mg/Kg and a complete tumor growth inhibition (97%) at a dose of 50mg/kg; and
• JBI-778 exhibited sustained brain exposure and significant tumor growth inhibition in an orthotopic glioblastoma model, translating into substantial survival advantage.

JBI-778 is currently being evaluated for the treatment of multiple cancers and IND-enabling studies have commenced.

PD-L1 expression is an immune evasion mechanism exploited by many cancers, such as melanoma, non-small cell lung cancer and breast cancer, which permits cancer progression and metastasis. Key highlights from the PD-L1/PD-1 study which examined the ability of JBI-1527 to inhibit PD-L1 and restore T-cell proliferation and function, include the following:

• JBI-1527 is a potent, selective inhibitor of PD-L1 which induces dimerization of the protein thereby alleviating PD-L1-induced suppression of T cell activation;
• The inhibitor shows similar modulation of cytokines as Pembrolizumab in BioMAP assay and competes with anti-PD-L1 blocking antibodysuggesting similar binding site on PD-L1; and
• In CT-26 and MC38-hPD-L1 syngeneic models, the small molecule showed strong tumor growth inhibition comparable to anti-PD-L1 mAb/Atezolizumab, and was well tolerated.

Studies to further assess JBI-1527 and additional compounds are underway.

Jubilant Therapeutics Inc. is developing a pipeline of novel, differentiated therapeutic assets; for partnership opportunity inquiries please contact bd@jubilanttx.com .

About Jubilant Therapeutics

Jubilant Therapeutics Inc. is a patient-centric biopharmaceutical company advancing potent and selective small molecule modulators to address unmet medical needs in oncology and autoimmune diseases. Its advanced discovery engine integrates structure-based design and computational algorithms to discover and develop novel, precision therapeutics against both first-in-class and validated but intractable targets in genetically-defined patient populations. The Company’s entrepreneurial-minded leadership and scientific teams strive for speed and efficiency by employing a business model that leverages the proven and synergistic capabilities of Jubilant Pharmova Limited’s value chain and shared services. Jubilant Therapeutics is headquartered in the U.S. and guided by globally renowned key opinion leaders and scientific advisory board members.  For more information, please visit www.jubilanttx.com or follow us on Twitter @JubilantTx and LinkedIn.

Media Contacts
Kari Watson, +1 781-235-3060
MacDougall
kwatson@macbiocom.com

Noida, March 31, 2021: Jubilant Bhartia Foundation and Schwab Foundation for Social Entrepreneurship, the sister organization of the World Economic Forum, announces the opening of entries for the 12th edition of the annual competition - Social Entrepreneur of the Year (SEOY) India Award 2021. In 2010 the Schwab Foundation for Social Entrepreneurship and Jubilant Bhartia Foundation joined hands to promote social innovation through the social entrepreneurship awards in India.

• Social Innovation Takes Off in India: A total of over 1600 unique social innovation applications have been received in 11 years.
• 11 years have seen a total of 523 women applications across India!
• Women Change Makers: 7 out of 11 winners of the SEOY India award are women social entrepreneurs.
• Turnover of participating social organisations range from Rs 1 million to Rs 600 million!
• More stringent evaluation: Two new parameters for evaluation of social entrepreneurs – Market-based and Technology-enabled solutions added this year.
• New Trends: In the recent years, sustainable farming and clean technology have emerged as new areas of social entrepreneurship

The application entry for the Social Entrepreneur of the Year (SEOY) India Award 2021’ will be accepted till April 30, 2021. Interested candidates may submit the application form available at jubilantbhartiafoundation.com or can email the filled form to jbf_seoy@jubl.com

The winner of the Social Entrepreneur of the Year (SEOY) India Award 2021 will be announced on October 7, 2021.

The award recognizes individuals and organizations who implement innovative, sustainable, and scalable solutions to address pressing issues faced by under-served communities to make inclusive growth a reality in India. They work in diverse areas such as health, education, employment, water, clean energy, building identity & entitlements, financial literacy, access to information and technology among others.

The participating individuals and organizations are evaluated on the key parameters of Market-based, Technology-enabled, Sustainability, Direct Social Impact, Reach & Scope, Replicability. The finalists will be selected following an intensive search and selection process, including expert reviews and site visits. The winner is selected by a prominent Jury consisting of eminent leaders and professionals from the Government, Business, Media, and Civil Society.

The winner of SEOY India will join the world’s largest network of social enterprises affiliated with The Schwab Foundation for Social Entrepreneurship, to engage, build and sustain their social enterprises. The winner is awarded by a prominent chief guest in a magnificent ceremony every year.

The Social Entrepreneur of the Year (SEOY) India Award aims to promote and celebrate leading social entrepreneurs and their unique ventures in India that help in addressing the various gaps in our society and country. Through providing recognition, the SEOY India Award hopes to inspire many other potential social entrepreneurs in India every year.

About Schwab Foundation for Social Entrepreneurship was co-founded by Professor Klaus Schwab, Founder and Executive Chairman of the World Economic Forum, and his wife Hilde. For twenty years, the Schwab Foundation for Social Entrepreneurship has supported the world’s leading social entrepreneurs in their efforts to create a more just, equitable, and sustainable world. The Schwab Foundation provides unparalleled platforms at the regional and global level to highlight and advance leading models of sustainable social innovation. Learn about us at www.schwabfound.org and follow us on Twitter: https://twitter.com/schwabfound

BEDMINSTER, New Jersey – March8, 2021 – Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, announced today the appointment of Luca Rastelli, Ph.D. as Chief Scientific Officer.Reporting directly to the Chief Executive Officer, Dr. Rastelli will lead all aspects of R&D for Jubilant Therapeutics and serve as a scientific liaison for the company to investors, partners and the medical community.

“Luca is a highly accomplishedscientist and oncology drug developerand it is a pleasure to welcome him to the team,” said Syed Kazmi, Ph.D., President and Chief Executive Officer of Jubilant Therapeutics.“His experience and leadership advancing novel targeted therapeutics will be integral as we execute our corporate vision.”

“I am thrilled to join Jubilant Therapeutics and I look forward to working with the experienced management and scientific teams to further the development of the company’sexciting andinnovative programsinto the clinic and beyond," said Luca Rastelli, Ph.D.

Dr. Rastelli brings to Jubilant Therapeutics more than 20 years of oncology drug discovery and development experience, as well as business development experience ranging from startups to large pharmaceutical companies. Most recently, he was Chief Scientific Officer at Kleo Pharmaceuticals where he led all aspects of R&D for the company and was instrumental in bringing a CD38 targeting compound based on Kleo’s novel ARM technology to the clinic for multiple myeloma.

Previously Dr. Rastelli was Vice President, Oncology at BioXcel Therapeutics where he helped bring the company to a successful IPO. He has held multiple preclinical and clinical project leadership positions at Boston Scientifics, CuraGen, Sopherion and EMD Serono (Merck Serono). He led the initial development of c-MET inhibitor TEPMETKO, approved for the treatment of METex14 positive NSCLC patients. Dr. Rastelli was also part of the initial development of the immuno-oncology antibody BAVENCIO, a PDL-1 inhibitor approved for several type of cancers. He received the American Brain Tumor Association's 25th Anniversary Translational grant for his work on Medulloblastoma tumors at the Department of Neuro-Oncology, MD Anderson Cancer Center. He is a named inventor on more than 10 issued patents and holds a Ph.D. in Molecular Biology from the University of Geneva.

About Jubilant Therapeutics

Jubilant Therapeutics Inc. is a patient-centric biopharmaceutical company advancing potent and selective small molecule modulators to address unmet medical needs in oncology and autoimmune diseases. Its advanced discovery engine integrates structure-based design and computational algorithms to discover and develop novel, precision therapeutics against both first-in-class and validated but intractable targets in genetically-defined patient populations. The Company’s entrepreneurial-minded leadership and scientific teams strive for speed and efficiency by employing a business model that leverages the proven and synergistic capabilities of Jubilant Pharmova Limited’s value chain and shared services. Jubilant Therapeutics is headquartered in the U.S. and guided by globally renowned key opinion leaders and scientific advisory board members.  For more information, please visit www.jubilanttx.com or follow us on Twitter @JubilantTx and LinkedIn.

Media Contacts
Kari Watson, +1 781-235-3060
MacDougall
kwatson@macbiocom.com

BEDMINSTER, New Jersey – February 25, 2021 – Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced a collaboration with Boston Children’s Hospital to evaluate peptidyl arginine deiminase 4 (PAD4) inhibitors under development by Jubilant Therapeutics to explore the modulation of  neutrophil extracellular traps (NETosis) in preclinical models of neutrophil regulation and rheumatoid arthritis (RA).

PAD4 is an enzyme that converts arginine to citrulline in histones and is highly expressed in neutrophils. Histone citrullination has been implicated in the formation of NETs which is believed to contribute to pro-inflammation and disease progression in many autoimmune disorders including RA, fibrosis, lupus and ARDS.

“We are pleased to announce our collaboration with Boston Children’s Hospital, whose reputation as the nation’s leading pediatric hospital and research enterprise make them an ideal partner as we endeavor to develop the next generation of therapeutics for autoimmune diseases,” said Syed Kazmi, President and Chief Executive Officer of Jubilant Therapeutics. “Dr. Denisa Wagner, the lead investigator, has extensive experience both in the PAD4 space and the role of NETs in pathological inflammation, and we’re thrilled to have her on the team.”

“It is my lab’s belief that PAD4-mediated NET formation profoundly contributes to many inflammatory and thrombotic diseases. We concluded this based on our work with mice deficient in PAD4. Specific PAD4 inhibitors, that are well tolerated by animals, would be great for pre-clinical and, later, human studies. We are excited to test the Jubilant Therapeutics inhibitors on isolated neutrophils and, later, in mouse models of RA that we have established in our laboratory” said Denisa Wagner, Ph.D., Senior Investigator, Program in Cellular and Molecular Medicine, and Edwin Cohn Professor of Pediatrics, Harvard Medical School.

About Boston Children’s Hospital

Boston Children’s Hospital is ranked the #1 children’s hospital in the nation by U.S. News & World Report and is the primary pediatric teaching affiliate of Harvard Medical School. Home to the world’s largest research enterprise based at a pediatric medical center, its discoveries have benefited both children and adults since 1869. Today, 3,000 researchers and scientific staff, including 8 members of the National Academy of Sciences, 21 members of the National Academy of Medicine and 12 Howard Hughes Medical Investigators comprise Boston Children’s research community. For more, visit our Discoveries blog and follow us on social media @BostonChildrens, @BCH_Innovation, Facebook and YouTube.

About Jubilant Therapeutics

Jubilant Therapeutics Inc. is a patient-centric biopharmaceutical company advancing potent and selective small molecule modulators to address unmet medical needs in oncology and autoimmune diseases. Its advanced discovery engine integrates structure-based design and computational algorithms to discover and develop novel, precision therapeutics against both first-in-class and validated but intractable targets in genetically-defined patient populations. The Company’s entrepreneurial-minded leadership and scientific teams strive for speed and efficiency by employing a business model that leverages the proven and synergistic capabilities of Jubilant Life Sciences Limited’s value chain and shared services. Jubilant Therapeutics is headquartered in the U.S. and guided by globally renowned key opinion leaders and scientific advisory board members.  For more information, please visit www.jubilanttx.com or follow us on Twitter @JubilantTx and LinkedIn.

Media Contacts

Jubilant Therapeutics Media Contact

Kari Watson, +1 781-235-3060
MacDougall
kwatson@macbiocom.com

Boston Children’s Hospital Media Contact

Bethany Tripp, 617-919-3656
Bethany.Tripp@childrens.harvard.edu

• Q3’FY21 Revenue at Rs 2,664 Crore vs. Rs 2,315 Crore in Q3’FY20; up 15% YoY
• Q3’FY21 EBITDA at Rs 653 Crore vs. Rs 513 Crore in Q3’FY20; up 27% YoY
• Q3’FY21 PAT at Rs 310 Crore vs. Rs 203 Crore in Q3’FY20; up 52% YoY
• Q3'FY21 EPS is Rs 19.5 vs. Rs 12.8 in Q3'FY20; up 52% YoY

The Board of Jubilant Pharmova Limited met today to approve financial results for the quarter ended December 31st, 2020.

Commenting on the Company’s performance, Mr. Shyam S Bhartia, Chairman and Mr. Hari S Bhartia, Co-Chairman & Managing Director, Jubilant Pharmova said:

“Q3'FY21 has witnessed a substantial improvement over the previous quarter despite continued adverse impact of the COVID-19 pandemic.

Pharma business delivered strong performance led by CDMO and Generics. We continue to see new business opportunities in CDMO, Generics and Specialty Pharma segments.

The company’s performance in the LSI business has been better due to good demand and improved pricing of select products.

Contract Research and Development Services business witnessed strong year-on-year growth in revenues led by healthy demand from customers.

We continue to expect strong performance in our businesses in Q4’FY21.

During 9M’FY21, the Company reduced net debt on a constant currency basis by Rs 570 Crore. This is in addition to Rs 514 crore reduction in net debt during FY20.

We received the final NCLT order approving the demerger of our LSI business. The demerger is effective from February 1, 2021 and creates separate and focused entities: Jubilant Pharmova for pharmaceuticals, contract research and development services and proprietary novel drugs businesses and Jubilant Ingrevia for life science products and innovative solutions business; that will help in unlocking shareholder value.”

Q3’FY21 Highlights

A. Consolidated

• Revenue at Rs 2,664 Crore, as compared with Rs 2,315 Crore in Q3'FY20; up 15% YoY
• Reported EBITDA at Rs 653 Crore as compared with Rs 513 Crore in Q3'FY20; up 27% YoY. EBITDA margin at 24.5% vs. 22.2% in Q3'FY20
• Finance costs at Rs 59 Crore vs. Rs 72 Crore in Q3'FY20
• Net Profit at Rs 310 Crore versus Rs 203 Crore in Q3’FY20. EPS of Rs 19.5 vs. Rs 12.8 in Q3’FY20; up 52% YoY
• Capital expenditure for the quarter was Rs 104 Crore

Segment Wise Analysis

B. Pharmaceuticals Segment

• Pharmaceuticals revenue was at Rs 1,692 Crore vs. Rs 1,450 Crore in Q3’FY20
• Pharmaceuticals EBITDA recorded at Rs 499 Crore as compared with Rs 411 Crore in Q3’FY20 with a margin of 29.5% as compared to 28.4% in Q3’FY20
• R&D spent during the quarter of Rs 45 Crore – 2.6% to segment sales. R&D debited to P&L is Rs 47 Crore – 2.8% to segment sales
• CMO business’ revenue grew based on strong demand from customers as well as new deals
• Five separate clinical and commercial supply agreements for COVID-19 treatment and vaccine candidates signed in 9M’FY21. Remdesivir of Gilead approved by the US FDA has been contributing to CMO revenue growth
• Started contract manufacturing of Eli Lily’s Bamlanivimab, a drug that has been granted Emergency Use Authorization by the US FDA for treatment of COVID-19 and COVID-19 vaccine candidate NVX-CoV2373 of Novavax, biotechnology company developing next-generation vaccines for serious infectious diseases
• Revenue growth during the quarter was also led by strong performance in key products in Generics segment, especially in the US market and also by launch of Remdesivir in various countries including India

C. Life Science Ingredients Segment

• LSI revenue was at Rs 893 Crore against Rs 797 Crore in Q3’FY20
• Strong growth witnessed in Nutrition and Health Solutions and Life Science Chemicals business driven by improved pricing in both the segments
• EBITDA at Rs 155 Crore increased by 55% YoY with margin of 17.4% as compared to 12.6% in Q3’FY20
• Strong improvement in profitability is driven by improvement in prices across several products as well as recovery in volumes in Nutrition and Life Sciences Chemicals

D. Contract Research and Development Services Segment

• Revenue at Rs 79 Crore increased by 17% YoY
• Reported EBITDA at Rs 29 Crore vs. Rs 22 Crore in Q3’FY20 with a margin of 36.4% vs. 32.9% in Q3’FY20
• Higher demand from biotech companies for integrated services, functional chemistry and DMPK
• Company continues to witness strong demand conditions in this business

9M’FY21 Highlights

E. Consolidated

• Consolidated Revenue at Rs 6,932 Crore vs. Rs 6,763 Crore in 9M’FY20
• EBITDA at Rs 1,457 Crore vs. Rs 1,438 Crore in 9M’FY20. EBITDA margin at 21.0% vs. 21.3% in 9M’FY20
• Finance costs at Rs 199 Crore down 8% YoY
• Net Profit at Rs 622 Crore vs. Rs 638 Crore in 9M’FY20. EPS of Rs 39.1 vs. Rs 40.0 in 9M’FY20
• Capex of Rs 285 Crore in 9M’FY21
• Net debt reduced by Rs 570 Crore during 9M’FY21

Segment Wise Analysis

F. Pharmaceuticals Segment

• Pharmaceuticals revenue at Rs 4,304 Crore vs. Rs 4,231 Crore in 9M’FY20
• EBITDA at Rs 1,020 Crore vs. Rs 1,127 Crore in 9M’FY20. Margin of 23.7% as compared to 26.6% in 9M’FY20

G. Life Science Ingredients Segment

• LSI revenue at Rs 2,413 Crore vs Rs 2,356 Crore in 9M’FY20
• EBITDA at Rs 418 Crore up 34% YoY with margin of 17.3% as compared to 13.3% in 9M’FY20

H. Contract Research and Development Services Segment

• Revenues at Rs 211 Crore up 20% YoY
• EBITDA was at Rs 67 Crore up from Rs 52 Crore in 9M’FY20

I. Business Outlook

• We continue to see improvement in demand in most of our business segments be it CMO, Generics, API or Life Science Ingredients
• Given the strong demand recovery and new business sign-ups, we believe COVID-19 is not likely to have a material impact on our overall performance during FY21, provided the pandemic situation does not materially deteriorate going forward
• Overall, we continue to see strong performance in our businesses in Q4’FY21
• For Pharmaceutical business, we continue to see strong performance in Q4
• For LSI business, we expect to achieve close to double-digit revenue growth and significant growth in EBITDA with higher margin and a very healthy cash generation in FY21

Bedminster, New Jersey – January 15, 2021 – Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced a collaboration with The Wistar Institute, an international leader in biomedical research, to evaluate the ability of Peptidyl Arginine  Deiminase 4 (PAD4) inhibitors provided by Jubilant Therapeutics to block neutrophil extracellular trap (NET) formation in the context of COVID-19 related cytokine storms.

PAD4 is an enzyme that catalyzes conversion of arginine to citrulline in proteins, including histones and is highly expressed in neutrophils. Histone citrullination has been implicated in Neutrophil Extracellular Trap (NET) formation and accumulating evidence suggests that NETs may be linked to the severity of COVID-19, as their formation is a result of pro-inflammatory cytokine release syndrome (CRS), or cytokine storms, produced by the body’s immune response to the SARS-CoV-2 virus. Cytokine storms are implicated in the development of acute respiratory distress syndrome (ARDS), which is the leading cause of death in patients infected with COVID-19. 

“We are very pleased to announce our collaboration with the renowned Wistar Institute,” said Syed Kazmi, President and Chief Executive Officer of Jubilant Therapeutics. “Even with COVID-19 vaccines on the horizon, we know its wrath will persist for some time to come and the need to reduce its death toll remains critical. Beyond COVID-19, understanding the potential of PAD4 inhibitors to address aberrant NET formation will be important due to their role in the pathogenesis of many disease states beyond viral infections.”

“This collaboration with Jubilant Therapeutics will further advance our comprehensive research efforts to find therapeutics to diminish cytokine storms and decrease COVID-19 symptom gravity,” said Yulia Nefedova, M.D., Ph.D., associate professor in the Immunology, Microenvironment & Metastasis Program at The Wistar Institute. “It is our hope that Jubilant Therapeutics’ inhibitors will prove successful in blocking NET formation to this end.” 

About The Wistar Institute

The Wistar Institute is an international leader in biomedical research with special expertise in cancer research and vaccine development. Founded in 1892 as the first independent nonprofit biomedical research institute in the United States, Wistar has held the prestigious Cancer Center designation from the National Cancer Institute since 1972. Wistar’s business development team is advancing Wistar science and technology development through creative partnerships. The Institute works actively to ensure that research advances move from the laboratory to the clinic as quickly as possible. wistar.org.

About Jubilant Therapeutics

Jubilant Therapeutics Inc. is a patient-centric biopharmaceutical company advancing potent and selective small molecule modulators to address unmet medical needs in oncology and autoimmune diseases. Its advanced discovery engine integrates structure-based design and computational algorithms to discover and develop novel, precision therapeutics against both first-in-class and validated but intractable targets in genetically-defined patient populations. The Company’s entrepreneurial-minded leadership and scientific teams strive for speed and efficiency by employing a business model that leverages the proven and synergistic capabilities of Jubilant Life Sciences Limited’s value chain and shared services. Jubilant Therapeutics is headquartered in the U.S. and guided by globally renowned key opinion leaders and scientific advisory board members.  For more information, please visit www.jubilanttx.com or follow us on Twitter @JubilantTx and LinkedIn.

Media Contacts

Jubilant Therapeutics Media Contact

Kari Watson, +1 781-235-3060
MacDougall
kwatson@macbiocom.com

The Wistar Institute Media Contact

Darien Sutton, C: 215-870-2048
dsutton@wistar.org

BEDMINSTER, New Jersey, Dec. 7, 2020 – Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced efficacy data from a study of JBI-802, its novel dual inhibitor of LSD1-HDAC6, in multiple acute myeloid leukemia (AML) models, and the identification of novel, undisclosed biomarkers that will aid in patient stratification. The data, presented today in a poster session at the 62nd American Society of Hematology (ASH) Virtual Annual Meeting, demonstrate superior efficacy in select AML models as compared to single agent inhibitors, with a unique mechanism of action.

“We are highly encouraged to verify that both LSD1 and HDAC6 mechanisms are operational with JBI-802 and the dual inhibition shows a stronger and more potent effect than the standalone inhibitors. We are also excited about the potential biomarkers we have identified specifically for the dual inhibitor which will be highly valuable in identifying sensitive patient populations,” said Syed Kazmi, President and Chief Executive Officer of Jubilant Therapeutics. “We believe JBI-802 could one day serve as a powerful therapeutic agent for the treatment of specific cancers, including myelodysplastic syndrome (MDS), select acute myeloid leukemia (AML) and solid tumor subsets.”

A link to the abstract, Novel Dual Inhibitor of LSD1-HDAC6/8 for Treatment of Cancer, is available through the ASH conference website.

Key highlights from the study of JBI-802 as compared to single agent LSD1 or HDAC6 selective inhibitors in AML models show:

• Both LSD1 and HDAC6 mechanisms are operational with JBI-802 resulting in stronger anti-proliferation and efficacy in a subset of cell lines; 
• Selective biomarkers are modulated with the dual inhibition of JBI-802 not seen by the single agent inhibitors, leading to the potential for patient stratification and the evaluation of treatment response; and
• JBI-802 has a superior efficacy, safety and tolerability profile.

About Jubilant Therapeutics

Jubilant Therapeutics Inc. is a patient-centric biopharmaceutical company advancing potent and selective small molecule modulators to address unmet medical needs in oncology and autoimmune diseases. Its advanced discovery engine integrates structure-based design and computational algorithms to discover and develop novel, precision therapeutics against both first-in-class and validated but intractable targets in genetically-defined patient populations. The Company’s entrepreneurial-minded leadership and scientific teams strive for speed and efficiency by employing a business model that leverages the proven and synergistic capabilities of Jubilant Life Sciences Limited’s value chain and shared services. Jubilant Therapeutics is headquartered in the U.S. and guided by globally renowned key opinion leaders and scientific advisory board members.  For more information, please visit www.jubilanttx.com or follow us on Twitter @JubilantTx and LinkedIn.

Media Contact
Kari Watson, +1 781-235-3060
MacDougall
kwatson@macbiocom.com

New Delhi, November 26, 2020: The Schwab Foundation for Social Entrepreneurship, the sister organisation of the World Economic Forum and the Jubilant Bhartia Foundation of Jubilant Bhartia Group today announced Ashraf Patel of Pravah & ComMutiny Youth Collective (CYC) as the winner of the Social Entrepreneur of the Year Award - India 2020. The award was presented by Smt. Smriti Zubin Irani, Hon. Minister of Women & Child Development & Textiles, Government of India at a virtual ceremony in presence of eminent personalities from different fields from across the world.

Congratulating the winner and appreciating the finalists of this year’s SEOY Award India 2020, Smt. Smriti Zubin Irani, Hon. Minister of Women & Child Development & Textiles, Government of India said, “I acknowledge and appreciate the contribution of Schwab Foundation and Jubilant Bhartia Foundation in celebrating social entrepreneurs. I would like to congratulate all the social entrepreneurs who have been considered by the esteemed jury for this prestigious award. This award today highlights to the rest of our country, that compassion is not only the most endearing but also an equally profitable business skill. Those who have come to this platform are the champions of digital India.”

The SEOY Award India 2020 winner – Ashraf Patel has been bringing revolutionary change through development of a generation of empathetic, sensitive youth change-makers in India. It is doing so, through psycho-social interventions and helping them build more inclusive identities & societies.

Prof Klaus Schwab, Founder & Executive Chairman, World Economic Forum and Co-Founder the Schwab Foundation for Social Entrepreneurship announced the winner of the SEOY Award India 2020 and added, “The World Economic Forum is very much involved in helping fight the pandemic. I am looking forward to having India very well represented in our activities because India is a major force in shaping the future and has to be very prominently engaged.”

Commending the winner and the finalists of SEOY Award India 2020, Mrs. Hilde Schwab, Chairperson and Co-Founder of the Schwab Foundation for Social Entrepreneurship said, “This year’s winner and finalists of the Social Entrepreneur of the Year India award all exemplify what our community is about – actors who have selflessly dedicated their lives to improving the state of the world around them. Social innovators are pioneering agents of change re-inventing the way our institutions operate, and are critical to achieving the Sustainable Development Goals by 2030. The current global pandemic has highlighted the crucial role of social innovators in identifying urgent needs and mobilizing responses to realities on the ground. The Schwab Foundation for Social Entrepreneurships is proud to have been partnering with Jubilant Bhartia Foundation over the past 11 years to award social innovators from India who are not only driving change but are also shifting organisations and systems towards a more just, inclusive, sustainable future.”

Applauding the winner and the finalists, Mr. Shyam S Bhartia, Chairman and Founder and Mr. Hari S Bhartia, Chairman & Co-Founder, Jubilant Bhartia Group and Founder Directors of Jubilant Bhartia Foundation, said, “Over last eleven years, we have seen a diversity of applications coming from the remotest corners of the country. The award process has so far seen over 1600 diverse applications. This year, inspite of trying times of pandemic, we received over 100 applications, with over one third women social entrepreneur applicants. The enthusiastic participation reflects the resilience & the tenacity of the social sector in these challenging times. It hearting to see that the finalists of this year have brought disruption in their own fields with their innovative ideas and approach. They have done path-breaking work in the fields of Healthcare, Youth Development and Solid Waste Management. Congratulations and kudos to the winner and the finalists for their extraordinary efforts. Their commitment to the cause is incomparable.”

Ashraf Patel, on winning the SEOY Award - India 2020 said, “This recognition for youth leadership has come at a moment when it was needed the most, the world right now is beset with inequality, conflict and environmental issues. Never before have we needed more collaboration and shared leadership with young people to create a better world.”

Ashraf Patel will join the Schwab Foundation for Social Entrepreneurship Community, the world’s largest and prestigious network of social innovators from around the world. The winner also participates in the annual and regional meetings of the World Economic Forum (WEF) which offer unique opportunities to engage with global decision makers from the public, corporate, media, academic and civil society sectors. The other finalists were Sujoy Santra of IKure, Kolkata & Sandeep Patel of NEPRA , Ahmedabad .

Celebrating its 11th year, the SEOY Award India has established itself as one of the most reputed and coveted awards for social entrepreneurs in India. The award recognises entrepreneurs who implement innovative, sustainable and scalable solutions to solve India’s social problems. In 2010, the Schwab Foundation for Social Entrepreneurship and Jubilant Bhartia Foundation came together to promote social innovation in India through the Social Entrepreneur of the Year (SEOY) India Award.

The SEOY Award - India 2020 received applications from 23 cities this year, with interventions in diverse fields including clean technology, media communication, youth development, disability, energy, enterprise development, labour conditions, microfinance, health & nutrition, sustainable farming and water & sanitation.

This year’s jury members for the award included, Shobhana Bhartia, Chairperson & Editorial Director, HT Media Ltd; Hilde Schwab, Chairperson & Co – Founder, Schwab Foundation for Social Entrepreneurship; Sudha Pillai, Board Member, Jubilant Life Sciences Ltd & Former Member Secretary, Planning Commission, Government of India; Uday Kotak, President, CII & Executive Vice Chairman and Managing Director, Kotak Mahindra Bank; Rakesh Mohan, President and Distinguished Fellow, Centre for Social & Economic Progress; Rohini Nilekani, Chairperson, Arghyam Foundation; P R Ganapathy, Regional Director, Stanford Seed, India and Dipesh Sutariya, Co-founder - EnAble India, Winner SEOY 2019.

About the winner:

Pravah has been facilitating the development of a generation of empathetic, sensitive youth change-makers in India through psycho-social interventions, helping them build more inclusive identities and societies bringing about revolutionary changes. With a belief that leaders are created in spaces which are safe, empowering, and inclusive, a unique approach to youth development in the form of the ‘5th Space’ has been developed. The 5th Space focuses on transforming young people by engaging them in deep self-exploration and supporting their social action experiments to become change-makers and awakened active citizens. It nurtures social inclusion, holistic development and fosters social hope by promoting feelings of freedom, ownership, love and learning and growth. With credence in its strategy and approach of creating ‘Abilities beyond skill’ Pravah has produced over 50 different designs of self to society journeys for different youth audiences ranging from urban middle-class young people to youth from rural and tribal backgrounds.

ComMutiny - The Youth Collective: Incubated by Pravah in collaboration with some of the best youth engaging organizations in the country acts as a vibrant national community of practice that promotes youth centric spaces through joint programming and public engagement on contemporary issues. A multi-sectoral formulation, called the vartaLeap coalition is also emerging from this eco-system to realise the mission of 'Every Youth a Jagrik and Every Space Nurturing Jagriks', that places youth duties and rights at the centre of all programming and policies in relation to youth and spaces that engage and influence young people in the country. Together Pravah and ComMutiny- The Youth Collective (CYC) have nurtured 6,80,000 young leaders, worked with over 1200 youth-centric organisations and 100 civil society groups across 17 states in the country.

Note to the Editors:

Schwab Foundation for Social Entrepreneurship was co-founded by Professor Klaus Schwab, Founder and Executive Chairman of the World Economic Forum, and his wife Hilde. For over twenty years, the Schwab Foundation for Social Entrepreneurship has supported the world’s leading social innovators in their efforts to create a more just, equitable, and sustainable world. The Schwab Foundation provides unparalleled platforms at the regional and global level to highlight and advance leading models of sustainable social innovation.

Learn more at www.schwabfound.org  and follow on: Twitter: @indiaseoy and Facebook: www.facebook.com/schwabfound

Jubilant Bhartia Foundation (JBF), established in 2007, is the not-for-profit organisation of the Jubilant Bhartia Group. It focuses on conceptualising and implementing the Corporate Social Responsibility initiatives (CSR) for the Group. The Jubilant Bhartia Foundation’s activities include various community development work, healthcare programs, cultural and sports events, environmental preservation initiative, vocational training, women empowerment, educational activities and promotion of Social Entrepreneurship.

Learn more at www.jubilantbhartiafoundation.com and follow on: Twitter: @indiaseoy and Facebook: www.facebook.com/IndiaSEOY

For media queries:
Vivek Prakash
Jubilant Bhartia Foundation
Ph: 9810674758
E-mail: vivek.prakash@jubl.com