News

On track towards Vision 2030 Strong growth in Revenue along with EBITDA & PAT Margin expansion Start of revenue from new & third line in CDMO Sterile Injectables business at Spokane, US

1. Normalised PAT is after adjusting for exceptional items and corresponding tax.

The Board of Jubilant Pharmova Limited met today to approve financial results for the quarter and half year ended September 30, 2025.

Commenting on the Company’s performance in Q2’FY26, Mr. Shyam S Bhartia, Chairman Jubilant Pharmova Limited and Mr. Hari S Bhartia, Co-Chairman & Non-Executive Director, Jubilant Pharmova Limited said, “We are pleased to announce revenue of Rs. 1,966 Cr. for Q2’FY26, which reflects a growth of 12% on YoY basis. Revenue growth is driven by incremental revenue generation that has started from the new & third line in CDMO Sterile Injectable business. We expect this growth momentum to further accelerate as we make progress in the second half of current financial year. EBITDA for the period grew by 13% YoY to Rs. 351 Cr. due to improved performance in Radiopharma, Allergy Immunotherapy, CDMO Sterile Injectables and CRDMO business. Normalised PAT grew by 21% to Rs. 124 Cr. on the back of improved operating performance and reduced finance cost. As we are consciously investing in Radiopharma, CDMO Sterile Injectables and CRDMO business to secure future growth, Net Debt / EBITDA increased from 1.1x in Mar’25 to 1.5x in Sep’25.

Q2’FY26 witnessed strong growth in Ruby-Fill® installs, increased demand in the US Allergy Immunotherapy market, launch of the third sterile injectables line at Spokane, and continued investments in CRDMO capabilities. The Company also completed the sale of its API business to Jubilant Biosys Limited. Generics business performance improved, with growth and profitability outlook strengthening. Proprietary Novel drugs pipeline continues to progress with JBI-802 and JBI-778 clinical trials.”

H1’FY26 Financial Highlights

• Revenue grew by 11% on a YoY basis to Rs. 3,867 Cr. on the back of growth in revenue across all business units.
• EBITDA grew by 13% on a YoY basis to Rs. 653 Cr. due to improved performance across all business units.
• Normalised PAT increased 32% YoY to Rs. 227 Cr due to improved operating performance and lower finance cost.
• Normalised PAT increased by 32% on a YoY basis to Rs. 227 Cr. on the back of improved operating performance and reduced finance cost. Reported PAT in H1’FY25 at Rs. 584 Cr. was higher because of one-time net exceptional income of Rs. 382 Cr.

Segmental Business Performance

Radiopharma

Radiopharmaceuticals Q2’FY26 revenue grew by 16% to Rs. 291 Cr. and EBITDA increased by 6% YoY at Rs. 127 Cr. The business continues to maintain a strong position in the high margin SPECT imaging product portfolio. In the Ruby-Fill® as we are able to demonstrate superior value proposition against competition, we are able to attract new channel partners. In the last one year, our Ruby-Fill® install base has grown by 24%. This improved scale is also helping to increase EBITDA margins in this product category. We are on track to introduce multiple new products in the PET and SPECT imaging from FY27 to FY29. The dosing for Phase 2 clinical trial for MIBG is complete and we are preparing data package to be submitted to FDA by H2’FY26.

Radiopharmacy Q2’FY26 revenue grew by 7% YoY to Rs. 607 Cr. EBITDA margins for Q2’FY26 stands at 1%. EBITDA margins remained weak due to increased competitive intensity in the SPECT business. Last year, two of our PET radiopharmacies have started distributing PYLARIFY®, which is an industry leading prostate cancer diagnostic imaging agent. We continue to see increase in revenue from PET radiopharmacies.

The proposed investment of US$ 50 million in PET radiopharmacy network is underway. This investment will take the overall PET radiopharmacy network to Nine (9) sites, thereby solidly positioning Jubilant Pharmova’s radiopharmacy network as the second largest in the US and shall drive the future business growth.

Allergy Immunotherapy - No. 2 in the US Sub-Cutaneous allergy immunotherapy market

As the sole supplier of Venom in the US, the business is expanding the overall market by increasing customer awareness. In the US Allergenic extracts, the business is working to increase revenues. The business is also working to increase penetration in the outside US markets.

In Q2’FY26, revenues grew by 14% to Rs. 194 Cr. on the back of growth in revenues from US market. EBITDA increased by 65% on a YoY basis to Rs. 76 Cr. EBITDA margins increased by 1210 bps on a YoY basis to 39%. We anticipate outside US sales to gradually improve.

CDMO Sterile Injectables – Leading contract manufacturer in North America, serving top global innovators

Q2’FY26 revenue grew by 30% to Rs. 393 Cr. due to increase in sales volume in Line 1 & 2 in Spokane and incremental revenue from Line 3 from Technology transfer programs. EBITDA grew by 6% to Rs. 94 Cr due to incremental EBITDA from Line 3. EBITDA margins were lower YoY due to shutdown at Montreal facility on account of internal quality system improvements and facility upgrades to address the current “OAI” status.

The capacity expansion program in Spokane, Washington, USA is on track. We successfully launched new Sterile Fill & Finish line, third at our Spokane Manufacturing Facility in Washington, US with a total investment of US $ 132 million.

The launch was marked by the successful production of the inaugural batch, initiating revenue generation from the technology transfer programs. Currently, we are running technology transfer programs for 5 to 6 products across multiple formats (vial sizes) on Line 3. We expect commercial batch production to start from FY27 post FDA approval of these products. In the wake of new tariffs imposed by the US Government, large innovator pharma companies are looking for high quality, US manufacturing facilities. Therefore, we are witnessing a very strong traction in Requests for Proposals (RFPs) for the New Line and expect to reach full utilisation for the Line 3 in the next 3 years. Also, the next phase of capacity expansion at Spokane, Line 4, is also on track and we expect to start commercial production by FY28.

CRDMO – Indian leader for integrated drug discovery & formidable API player

In Q2’FY26, the Drug Discovery business revenue grew by 7% to Rs. 162 Cr. EBITDA margins for Q2’FY26 stands at 21%. Revenue continue to increase due to increase in revenue from large Pharma customers. We have integrated new R&D facility in France and are now investing in business development. EBITDA margins are lower YoY due to change in project mix and investment in business development. Overall, the medium term outlook continues to be positive on the back of the increase in large pharma clients and the addition in new capabilities.

The API business revenue grew by 8% to Rs. 137 Cr in Q2’FY26. EBITDA for the quarter increased by 70% YoY to Rs. 21 Cr. EBITDA margins are higher YoY due to continued focus on profitable products . We have completed the sale and transfer of API Business to Jubilant Biosys Limited, a wholly owned subsidiary of the Company. This transaction has resulted in housing of the drug discovery business and CDMO API business in a single business entity. This combined platform will improve the operational efficiency in the business and lead to superior brand recall of “Jubilant Biosys Limited” as provider of end-to-end CRDMO services by the large pharmaceutical & Biotech customers. The transaction will also help to improve asset utilisation of API business by improving the revenue mix towards Custom manufacturing & CDMO.

Generics – Building a growing, profitable & agile business model

In Q2’FY26, the Generics business revenue stands at Rs. 167 Cr. EBITDA for the period stands at Rs. 14 Cr. In H1’FY26, EBITDA margins increased by 460 basis points to 8%.

We plan to launch 6 to 8 products per annum in our US and non-US international markets. In line with our plan, we are ramping up exports to the US markets in a meaningful and gradual manner. We have also started supply of products from our Contract manufacturing partners to the US market.

Proprietary Novel Drugs – Innovative biopharmaceutical company developing breakthrough therapies

The global clinical trials for our lead programs, Phase II trial for JBI -802 for Essential Thrombocythemia (ET) and other Myeloproliferative Neoplasms (MPN) and Phase I trial for JBI -778 for non-small cell lung cancer (NSCLC) and high grade Glioma are actively enrolling patients and progressing in line with our expectations.

About Jubilant Pharmova Limited

Jubilant Pharmova Limited (formerly Jubilant Life Sciences Limited) is a company with a global presence that is involved in Radiopharma, Allergy Immunotherapy, CDMO Sterile Injectables, Contract Research Development and Manufacturing Organisation (CRDMO), Generics and Proprietary Novel Drugs businesses. In the Radiopharma business, the Company is involved in the manufacturing and supply of Radiopharmaceuticals with a network of 45 radiopharmacies in the US. The Company’s Allergy Immunotherapy business is involved in the manufacturing and supply of allergic extracts and venom products in the US and in some other markets such as Canada, Europe and Australia. Jubilant Pharmova Limited through its CDMO Sterile Injectables business offers manufacturing services including sterile fill and finish injectables (both liquid and lyophilization), full-service ophthalmic offer (liquids, ointments & creams) and ampoules. The CRDMO business of the Company includes the Drug Discovery Services business that provides contract research and development services through two world-class research centers in Bengaluru and Noida in India and one in France. The CDMO-API business that is involved in the manufacturing of Active Pharmaceutical Ingredients. Jubilant Therapeutics is involved in the Proprietary Novel Drugs business and is an innovative biopharmaceutical company developing breakthrough therapies in the area of oncology and auto-immune disorders. The Company operates multiple manufacturing facilities that cater to all the regulated markets including USA, Europe and other geographies. Jubilant Pharmova Limited has a team of around 5,500 multicultural people across the globe. The Company is well recognised as a ‘Partner of Choice’ by leading pharmaceuticals companies globally.

For more information, please contact:

Disclaimer

Statements in this document relating to future status, events, or circumstances, including but not limited to statements about plans and objectives, the progress and results of research and development, potential product characteristics and uses, product sales potential and target dates for product launch are forward-looking statements based on estimates and the anticipated effects of future events on current and developing circumstances. Such statements are subject to numerous risks and uncertainties and are not necessarily predictive of future results. Actual results may differ materially from those anticipated in the forward-looking statements. Jubilant Pharmova may, from time to time, make additional written and oral forward looking statements, including statements contained in the company’s filings with the regulatory bodies and its reports to shareholders. The company assumes no obligation to update forward-looking statements to reflect actual results, changed assumptions or other factors.

Noida, India & Spokane, Washington, US - October 10, 2025 Jubilant Pharmova Limited announced today that Jubilant HollisterStier LLC (JHS)—a wholly owned subsidiary and a leading North American pharmaceutical contract manufacturer, specialising in sterile injectables and serving top global innovator pharma companies—successfully launched its New Sterile Fill & Finish line, third at its Spokane Manufacturing Facility in Washington, US. The launch was marked by the successful production of the inaugural batch, initiating revenue generation from the new Line. This milestone denotes a significant advancement in Jubilant HollisterStier’s multi-phase expansion strategy and brings an additional 50% capacity at its Spokane manufacturing facility.

The New Line features advanced isolator technology designed to deliver enhanced sterility assurance, throughput and operational precision. Built to meet the highest global regulatory standards, the New Line significantly enhances the Company’s ability to support complex injectable programs across a broad range of therapeutic areas. The US$ 132 million investment towards this New Third Line, reflects the Company’s long-term commitment to innovation, quality and supply chain resilience.

Together with the commissioning of its upcoming Fourth Line, JHS is on track to double its total sterile injectable manufacturing capacity at its Spokane facility in the US. This strategic investment further reinforces JHS’ leadership in domestic US pharmaceutical manufacturing. By expanding its infrastructure and increasing onshore capacity, the Company is contributing to US national health security and helping to reduce reliance on offshore supply chains—delivering a more resilient and agile pharmaceutical manufacturing ecosystem.

Commenting on the development, Chris Preti, CEO - CDMO Sterile Injectables said, “Launching our Third Line is more than a milestone for us—it’s a defining moment in Jubilant HollisterStier’s journey. This expansion also reflects our deep-rooted commitment, to continued growth, technological excellence and the community at Spokane. With Third Line now operational and Fourth Line on the horizon, we are not just doubling our capacity, we’re building a future that will create hundreds of new jobs, strengthen the US pharmaceutical supply chain and reaffirm our role as a trusted partner in delivering life-saving therapies to patients around the world.” He further added, “In the wake of new tariffs imposed by the US Government, large innovator pharma companies are looking for high quality, US manufacturing facilities. Therefore, we are witnessing a very strong traction in Requests for Proposals (RFPs) for the New Line. We expect to reach the full utilisation for the New Line in the next 3 years.”

Trusted by 5 of the top 20 global pharma companies as partners, JHS has a 92% customer retention rate that reflects high level of customer satisfaction. It also has a proven track-record, with regulatory organisations like the US FDA, EMA, PMDA Japan, Health Canada, ANVISA Brazil and other bodies in over 140 countries worldwide.

About Jubilant HollisterStier LLC

Jubilant HollisterStier LLC is a subsidiary of Jubilant Pharma Holding Inc., which is a wholly-owned subsidiary of Jubilant Pharmova Limited. Jubilant HollisterStier is a leading Contract Development & Manufacturing Organisation specialising in comprehensive sterile fill-finish, lyophilization and ophthalmic manufacturing services. With decades of proven expertise and advanced facilities in Spokane, Washington, and Montréal, Québec, JHS delivers high-quality pharmaceutical products to meet the rigorous standards of global healthcare markets and patients worldwide. Its flexible, collaborative partnership model empowers clients to accelerate speed to market while maintaining full regulatory confidence and manufacturing excellence.

About Jubilant Pharmova Limited

Jubilant Pharmova Limited (formerly Jubilant Life Sciences Limited) is a company with a global presence that is involved in Radiopharma, Allergy Immunotherapy, CDMO Sterile Injectables, Contract Research Development and Manufacturing Organisation (CRDMO), Generics and Proprietary Novel Drugs businesses. In the Radiopharma business, the Company is involved in the manufacturing and supply of Radiopharmaceuticals with a network of 45 radiopharmacies in the US. The Company’s Allergy Immunotherapy business is involved in the manufacturing and supply of allergic extracts and venom products in the US and in some other markets such as Canada, Europe and Australia. Jubilant Pharmova Limited through its CDMO Sterile Injectables business offers manufacturing services including sterile fill and finish injectables (both liquid and lyophilization), full-service ophthalmic offer (liquids, ointments & creams) and ampoules. The CRDMO business of the Company includes the Drug Discovery Services business that provides contract research and development services through two world-class research centers in Bengaluru and Noida in India and one in France. The CDMO-API business that is involved in the manufacturing of Active Pharmaceutical Ingredients. Jubilant Therapeutics is involved in the Proprietary Novel Drugs business and is an innovative biopharmaceutical company developing breakthrough therapies in the area of oncology and auto-immune disorders. The Company operates multiple manufacturing facilities that cater to all the regulated markets including USA, Europe and other geographies. Jubilant Pharmova Limited has a team of around 5,500 multicultural people across the globe. The Company is well recognised as a ‘Partner of Choice’ by leading pharmaceuticals companies globally.

For more information, please contact:

Disclaimer

Statements in this document relating to future status, events, or circumstances, including but not limited to statements about plans and objectives, the progress and results of research and development, potential product characteristics and uses, product sales potential and target dates for product launch are forward-looking statements based on estimates and the anticipated effects of future events on current and developing circumstances. Such statements are subject to numerous risks and uncertainties and are not necessarily predictive of future results. Actual results may differ materially from those anticipated in the forward-looking statements. Jubilant Pharmova may, from time to time, make additional written and oral forward looking statements, including statements contained in the company’s filings with the regulatory bodies and its reports to shareholders. The company assumes no obligation to update forward-looking statements to reflect actual results, changed assumptions or other factors.

On track towards Vision 2030
Solid growth momentum along with EBITDA & PAT margin expansion
Strong customer traction in CDMO Sterile Injectable business

1. Normalised PAT is after adjusting for exceptional items and tax.
In Q1’FY25, Reported PAT at Rs.482 Cr. was higher due to one-time net exceptional income of Rs. 396 Cr

The Board of Jubilant Pharmova Limited met today to approve financial result for the quarter ended June 30, 2025.

Commenting on the Company’s performance in Q1’FY26, Mr. Shyam S Bhartia, Chairman Jubilant Pharmova Limited and Mr. Hari S Bhartia, Co-Chairman & Non-Executive Director, Jubilant Pharmova Limited said, “We are pleased to announce revenue of Rs. 1,901 Cr. in Q1’FY26, growth of 10% over last year, same quarter. It is heartening to note is that we delivered solid revenue growth across all of our business units and we expect this growth momentum to grow stronger as we move forward. EBITDA grew by 14% YoY to Rs. 302 Cr. Ebitda margins expanded by 60 basis points on the back of improved operating performance across CRDMO and Generics. Normalised PAT grew by 48% to Rs. 103 Cr. on the back of improved operating performance and reduced finance cost. Reported PAT in Q1’FY25 at Rs. 482 Cr. was higher because of one time net exceptional income of Rs. 396 Cr. As we are consciously investing in Radiopharma, CDMO Sterile Injectables and CRDMO business to secure future growth, Net Debt / EBITDA increased marginally from 1.1x in Mar’25 to 1.2x in Jun’25 on the back of increased capex intensity.

During Q1’FY26, we saw continued growth momentum from Ruby-Fill® and PET radiopharmacies. In the Allergy Immunotherapy, we witnessed increase in demand from the US. In the CDMO Sterile Injectables, strong customer traction for Line 3 in Spokane continues. In the CRDMO business, we integrated the new R&D facility in France and are now investing in business development initiatives. In the Generics business, we are foreseeing growth & profitability improvement. Lastly, in our Proprietary Novel drugs business, we continue to progress in dosing patients in JBI-802 and JBI-778 clinical trials.”

Q1’FY26 Financial Highlights

In Q1’FY26, Revenue grew by 10% on a YoY basis to Rs. 1,901 Cr. on the back of growth in revenue across all business units. EBITDA grew by 14% on a YoY basis to Rs. 302 Cr. due to improved performance in CRDMO and Generics. Q1’FY26 normalised PAT increased by 48% on a YoY basis to Rs. 103 Cr. on the back of improved operating performance and reduced finance cost. Reported PAT in Q1’FY25 at Rs. 482 Cr. was higher because of one time exceptional income of Rs. 396 Cr.

Segmental Business Performance

Radiopharma - Leading Radiopharmaceutical manufacturer & 2nd largest Radiopharmacy network in the US

Radiopharmaceuticals Q1’FY26 revenue grew by 3% to Rs. 271 Cr. and EBITDA remained stable YoY at Rs. 126 Cr. The business continues to maintain a strong position in the high margin SPECT imaging product portfolio. On the PET side, The Ruby-Fill® installations are increasing. We are on track to introduce multiple new products in the PET and SPECT imaging from FY27 to FY29. The dosing for Phase 2 clinical trial for MIBG is complete and we are preparing data package to be submitted to FDA by H2’FY26.

Radiopharmacy Q1’FY26 revenue grew by 5% YoY to Rs. 598 Cr. EBITDA margins for Q1’FY26 stands at 2%. EBITDA margins remained weak due to increased competitive intensity in the SPECT business. In H2’FY25, two of our PET radiopharmacies have started distributing PYLARIFY®, which is an industry leading prostate cancer diagnostic imaging agent. We continue to see increase in revenue from PET radiopharmacies.

The proposed investment of US$ 50 million in PET radiopharmacy network is underway. This investment will take the overall PET radiopharmacy network to Nine (9) sites, thereby solidly positioning Jubilant Pharmova’s radiopharmacy network as the second largest in the US and shall drive the future business growth.

Allergy Immunotherapy - No. 2 in the US Sub-Cutaneous allergy immunotherapy market

As the sole supplier of Venom in the US, the business is expanding the overall market by increasing customer awareness. In the US Allergenic extracts, the business is working to increase revenues. The business is also working to increase penetration in the outside US markets.

In Q1’FY26, revenues grew by 8% to Rs. 181 Cr. on the back of growth in revenues from US market. EBITDA remained stable YoY at Rs. 63 Cr. EBITDA margin for Q1’FY26 stands at 35%. We anticipate outside US sales to gradually improve.

CDMO Sterile Injectables – Leading contract manufacturer in North America, serving top global innovators

Q1’FY26 revenue grew by 14% to Rs. 370 Cr. due to increase in sales volume. EBITDA grew by 9% to Rs. 62 Cr. EBITDA margins are lower QoQ due to annual maintenance shutdown at Spokane facility. The capacity expansion program in Spokane, Washington, USA is on track. Media fills had been successfully completed on Line 3 and the technology transfer programs are underway. The large innovator pharma companies are now looking to create an alternate manufacturing site in the US as a risk management strategy to mitigate any potential tariff’s imposed by the US govt. In light of the same, we are starting to see excellent traction in Requests for Proposals (RFPs) for Line 3 including from Big Pharma. We expect to finalise these within FY26. The commercial production on line 3 is expected to start in FY26. We also expect to reach peak utilisation for Line 3 in three years post start of commercial production vs four years, expected earlier. The Montreal facility continued operations after successful implementation of corrective and preventive actions.

CRDMO – Indian leader for integrated drug discovery & formidable API player

In Q1’FY26, the Drug Discovery business revenue grew by 42% to Rs. 161 Cr. EBITDA grew by 46% to Rs. 32 Cr. Revenue continue to increase due to increase in revenue from large Pharma customers. We have integrated new R&D facility in France and are now investing in business development. EBITDA margins lower QoQ due to change in project mix and investment in business development. Overall, the medium term outlook continues to be positive on the back of the increase in large pharma clients and the addition in new capabilities.

The API business revenue grew by 9% to Rs. 141 Cr in Q1’FY26. EBITDA grew by 36% to Rs. 22 Cr. EBITDA margins improved by 310 basis points due to profitable product mix.

We have proposed sale and transfer of API Business to Jubilant Biosys Limited, a wholly owned subsidiary of the Company. This transaction will result in housing of the drug discovery business and CDMO API business in a single business entity. This combined platform will improve the operational efficiency in the business and lead to superior brand recall of “Jubilant Biosys Limited” as provider of end-to-end CRDMO services by the large pharmaceutical & Biotech customers. The transaction will also help to improve asset utilisation of API business by improving the revenue mix towards Custom manufacturing & CDMO.

Generics – Building a growing, profitable & agile business model

In Q1’FY26, the Generics business revenue grew by 7% to Rs. 166 Cr. EBITDA for the period stands at Rs. 12 Cr. Revenue increase is primarily driven by Non US markets. EBITDA margins improved by 1,400 basis points YoY due to focus on profitable products.

We plan to launch 6 to 8 products per annum in our US and non-US international markets. In line with our plan, we are ramping up exports to the US markets in a meaningful and gradual manner. We have also started supply of products from our Contract manufacturing partners to the US market.

Proprietary Novel Drugs – Innovative biopharmaceutical company developing breakthrough therapies

The global clinical trials for our lead programs, Phase II trial for JBI -802 for Essential Thrombocythemia (ET) and other Myeloproliferative Neoplasms (MPN) and Phase I trial for JBI -778 for non-small cell lung cancer (NSCLC) and high grade Glioma are actively enrolling patients and progressing in line with our expectations.

About Jubilant Pharmova Limited

Jubilant Pharmova Limited (formerly Jubilant Life Sciences Limited) is a company with a global presence that is involved in Radiopharma, Allergy Immunotherapy, CDMO Sterile Injectables, Contract Research Development and Manufacturing Organisation (CRDMO), Generics and Proprietary Novel Drugs businesses. In the Radiopharma business, the Company is involved in the manufacturing and supply of Radiopharmaceuticals with a network of 45 radiopharmacies in the US. The Company’s Allergy Immunotherapy business is involved in the manufacturing and supply of allergic extracts and venom products in the US and in some other markets such as Canada, Europe and Australia. Jubilant Pharmova Limited through its CDMO Sterile Injectables business offers manufacturing services including sterile fill and finish injectables (both liquid and lyophilization), full-service ophthalmic offer (liquids, ointments & creams) and ampoules. The CRDMO business of the Company includes the Drug Discovery Services business that provides contract research and development services through two world-class research centers in Bengaluru and Noida in India and one in France. The CDMO-API business that is involved in the manufacturing of Active Pharmaceutical Ingredients. Jubilant Therapeutics is involved in the Proprietary Novel Drugs business and is an innovative biopharmaceutical company developing breakthrough therapies in the area of oncology and auto-immune disorders. The Company operates multiple manufacturing facilities that cater to all the regulated markets including USA, Europe and other geographies. Jubilant Pharmova Limited has a team of around 5,500 multicultural people across the globe. The Company is well recognised as a ‘Partner of Choice’ by leading pharmaceuticals companies globally.

For more information, please contact:

Disclaimer

Statements in this document relating to future status, events, or circumstances, including but not limited to statements about plans and objZectives, the progress and results of research and development, potential product characteristics and uses, product sales potential and target dates for product launch are forward-looking statements based on estimates and the anticipated effects of future events on current and developing circumstances. Such statements are subject to numerous risks and uncertainties and are not necessarily predictive of future results. Actual results may differ materially from those anticipated in the forward-looking statements. Jubilant Pharmova may, from time to time, make additional written and oral forward looking statements, including statements contained in the company’s filings with the regulatory bodies and its reports to shareholders. The company assumes no obligation to update forward-looking statements to reflect actual results, changed assumptions or other factors.

Noida, June 26, 2025 The Jubilant Bhartia Foundation, in partnership with the Schwab Foundation for Social Entrepreneurship (sister organisation of The World Economic Forum) are proud to announce the finalists of the 16th edition of the ‘Social Entrepreneur of the Year’ India Award 2025. This award recognises and celebrates the outstanding contributions of social innovators in India who have transformed lives and communities through their exceptional socio-business initiatives.

The selected Finalists and their organisations are:

• Kalpana Sankar, Hand in Hand India and Belstar Microfinance, Tamil Nadu – www.hihindia.org
• Piyush Tewari, SaveLIFE Foundation, New Delhi – www.savelifefoundation.org
• Nagakarthik MP, Sauramandala Foundation, Meghalaya – www.sauramandala.org
• Sumita Ghose, Rangsutra Crafts India, New Delhi – www.rangsutra.com

The final winner will be announced on August 8, 2025, in a ceremony in New Delhi, where global leaders and representatives from various sectors will gather to celebrate social entrepreneurship.

Selection Criteria:

• Addressing social inequalities, exclusion and marginalisation
• Unique social model or initiative
• Potential for sustainable, systemic-level change

The Jubilant Bhartia Foundation conducted background research, team interactions, impact assessments, expert reviews and reference checks to select these four high-impact social innovators.

The winner will join the Schwab Foundation’s global network of social innovators and can apply for the Hindustan Times Fellowship for the Stanford Seed Transformation program.

Statistics:

• 172 applications received in 2025
• 60% were first-time applicants
• Top sectors: Education, Healthcare, Livelihood, Agriculture, Clean Technology

The shortlisted finalists have contributed to:

• Poverty alleviation via Self-Help Groups, education and livelihood generation
• Road safety and trauma care through policy advocacy and tech-driven solutions
• Socioeconomic change in remote areas through solar-powered public health and rural entrepreneurship
• Empowering rural artisans via cooperatives, skill-building, and fair wages

Meet the Finalists

Kalpana Sankar
Organisation: Hand in Hand India and Belstar Microfinance
Website: hihindia.org
Year Established: 2004
Sector: Rural Development and Poverty Alleviation

About: Dr. Kalpana Sankar, a nuclear physicist turned visionary social entrepreneur, is the Managing Director of Belstar Microfinance Ltd. and Co-founder & Chairperson of Hand in Hand India. She has impacted over 10 million women through employment and enterprise development. Her five-pillar model integrates financial inclusion, education, healthcare, sanitation, and livelihoods. Hand in Hand India has mobilised 5.75 million women into SHGs, disbursed ?34,000 crore in microfinance, transitioned 373,040 children from labour to school, and revived 45,115 hectares for organic farming. She has received the Nari Shakti Puraskar and Princess Sabeeka Global Award.

Piyush Tewari
Organisation: SaveLIFE Foundation
Website: savelifefoundation.org
Year Established: 2008
Sector: Public Health

About: Piyush Tewari, a Harvard graduate and ex-private equity professional, founded SaveLIFE Foundation after a personal tragedy. He led the enactment of India’s first Good Samaritan Law and created the Zero-Fatality Solutions program that cut road deaths by 67% in high-risk zones. His organisation’s work spans safer road design, enforcement, trauma response, and community engagement.

Nagakarthik MP
Organisation: Sauramandala Foundation
Website: sauramandala.org
Year Established: 2018
Sector: Digital Governance and Poverty Alleviation

About: Nagakarthik MP, inspired to bridge policy and ground realities, founded Sauramandala Foundation using a community-led, co-creation approach. Their Centre for Accelerated Development (CFAD) empowers underserved communities in Northeast India. With support to 450+ rural entrepreneurs and 10,000 youth, their clean energy initiatives now power 350+ health centres. Their participatory model is transforming public policy to be locally informed and scalable.

Sumita Ghose
Organisation: Rangsutra Crafts India
Website: rangsutra.com
Year Established: 2006
Sector: Women Empowerment and Livelihood

About: After her husband’s death, Sumita Ghose founded Rangsutra to connect rural artisans to global markets. Rangsutra has empowered over 8,000 artisans—70% of them women—through design workshops, enterprise training and shareholder ownership. Their impact extends to over 50,000 beneficiaries. Rangsutra blends heritage with innovation to deliver dignity and livelihood to India’s craft communities.

About Us

Schwab Foundation for Social Entrepreneurship: In partnership with the World Economic Forum, it’s a global platform supporting systemic change through social innovation since 1998. Co-founded by Klaus and Hilde Schwab.

• Website: www.schwabfound.org
• Facebook: facebook.com/schwabfound
• Instagram: instagram.com/schwabfoundation
• LinkedIn: linkedin.com/company/schwab-foundation

Jubilant Bhartia Foundation (JBF): Founded in 2007 as the CSR arm of Jubilant Bhartia Group, JBF works in community development, healthcare, environment, education, sports, and social entrepreneurship.

• Website: www.jubilantbhartiafoundation.com
• Twitter: @indiaseoy
• Facebook: facebook.com/IndiaSEOY

Media Contact:
Vivek Prakash
Jubilant Bhartia Foundation
Ph: +91 120 436 1804; 9810674758
Email: vivek.prakash@jubl.com

On track towards realizing Vision 2030
Sustained growth momentum, EBITDA margin expansion and Net Debt / EBITDA reduction Strong industry tailwinds in CDMO Sterile Injectable business in the post tariff world

1. Normalised PAT is after adjusting for exceptional items and tax

Commenting on the Company’s performance in FY25, Mr. Shyam S Bhartia, Chairman Jubilant Pharmova and Mr. Hari S Bhartia, Co-Chairman & Non-Executive Director, said, “We are pleased to announce revenue of Rs. 7,235 Cr. in FY25, growth of 8% over last year. We delivered robust revenue growth across Radiopharma, Allergy Immunotherapy, CDMO Sterile Injectables and CRDMO businesses. EBITDA grew by 24% to Rs. 1,230 Cr. on the back of strong operating performance across all business units. EBITDA margins for the year expanded by 220 basis points. Reported PAT grew by 1,050% to Rs. 836 Cr., while normalised PAT grew by 112% to Rs. 415 Cr. on the back of improved operating performance and reduced finance cost. Net Debt / EBITDA reduced from 2.5x in Mar’24 to 1.1x in Mar’25 on the back of voluntary debt prepayment of USD 125 million in FY25.

In Feb’2025, we outlined our Vision 2030, which is to double our revenues from FY24 to FY30, improve EBITDA margins to 23% to 25% range, reduce Net debt to zero and grow Return on Capital to high teens. Our FY25 financial performance takes us one-step closer to our Vision.

During the year, the Company started distributing Pylarify®, an industry leading prostate cancer diagnostic imaging agent from PET radiopharmacies, completed Media Fills on Line 3 in CDMO Sterile Injectables, added strategic capabilities in the area of Biologics and Antibody drug conjugates in Drug Discovery, reached profitability in the Generics business and dosed first patients in JBI-802 and JBI-778 clinical trials.

The large innovator pharma companies, for their US requirements, are now looking to create an alternate manufacturing site in the US as a risk management measure in the event of tariff imposed by the US govt. Therefore, the company is starting to see excellent traction in the CDMO Sterile Injectable business for new lines in the Spokane facility. We expect to reach peak utilisation for Line 3 in 3 years from start of commercial production vs 4 years, expected earlier.”

Q4’FY25 Financial Highlights

In Q4’FY25, Revenue grew by 10% on a YoY basisto Rs. 1,929 Cr. on the back of growth in revenue across Radiopharma, Allergy Immunotherapy, CDMO Sterile Injectables and CRDMO Business. EBITDA grew by 23% on a YoY basis to Rs. 357 Cr. due to improved performance in Radiopharmaceuticals, Allergy Immunotherapy, CDMO Sterile Injectables and CRDMO. Q4’FY25 normalised PAT increased by 127% on a YoY basis to Rs. 139 Cr. on the back of improved operating performance.

Segmental Business Performance

Radiopharma - Leading Radiopharmaceutical manufacturer & 2nd largest Radiopharmacy network in the US

Radiopharmaceuticals FY25 revenue grew by 13% to Rs. 1,074 Cr. and EBITDA grew by 6% to Rs. 505 Cr. The business continues to maintain a strong position in the high margin SPECT imaging product portfolio. On the PET side, The RubyFill® installations are increasing. We are on track to introduce multiple new products in the PET and SPECT imaging from FY27 to FY29. The dosing for Phase 2 clinical trial for MIBG is complete and we are preparing data package to be submitted to FDA by H2’FY26.

Radiopharmacy FY25 revenue grew by 13% YoY to Rs. 2,314 Cr. EBITDA margins for the year stands at 1%. During the year, EBITDA margins reduced due to increased competitive intensity in the SPECT business and global Technetium shortage. In H2’FY25, our two PET radiopharmacies have started distributing PYLARIFY®, which is an industry leading prostate cancer diagnostic imaging agent. We expect margins to improve next year on the back of increase in revenue mix from PET radiopharmacies.

The proposed investment of US$ 50 million in PET radiopharmacy network is underway. This investment will take the overall PET radiopharmacy network to Nine (9) sites, thereby solidly positioning Jubilant Pharmova’s radiopharmacy network as the second largest in the US and shall drive the future business growth.

Allergy Immunotherapy - No. 2 in the US Sub-Cutaneous allergy immunotherapy market

As the sole supplier of Venom in the US, the business is expanding the overall market by increasing customer awareness. In the US Allergenic extracts, the business continue to grow revenues. The business is also working to increase penetration in the outside US markets.

In FY25, Revenues grew by 3% to Rs. 701 Cr. EBITDA margins for the year stands at 35%. In line with our expectations, normalized production resumed in Q4’FY25. We anticipate outside US sales to also gradually improve.

CDMO Sterile Injectables

FY25 revenue grew by 14% to Rs. 1,272 Cr. and EBITDA grew by 52% to Rs. 292 Cr. Q4’FY25 EBITDA margins increased by 540 basis points to 28%. The capacity expansion program in Spokane, Washington, USA is on track. Media fills had been successfully completed on Line 3 and the technology transfer programs are underway. The large innovator pharma companies are now looking to create an alternate manufacturing site in the US as a risk management strategy to mitigate any potential tariff’s imposed by the US govt. In light of that, we are starting to see excellent traction in Requests for Proposals (RFPs) for Line 3 including from Big Pharma. We expect to finalise these within FY26. The commercial production on line 3 is expected to start in FY26. We also expect to reach peak utilisation for Line 3 in 3 years post start of commercial production vs 4 years, expected earlier. The Montreal facility continued operations after successful implementation of corrective and preventive actions.

CRDMO

In FY25, the Drug Discovery business revenue grew by 27% to Rs. 570 Cr. and EBITDA grew by 29% to Rs. 136 Cr. In FY25, revenue increased sharply due to increase in revenue from new contracts from large Pharma customers. We added 3 large Pharma customers during the year. We announced strategic partnership with Pierre Fabre, France to expand our footprint in Europe in areas like Biologics (mAbs) and Antibody Drug Conjugate (ADC). Overall, the medium term outlook continues to be positive on the back of the increase in large pharma clients, CDMO revenues and the addition in new capabilities.

The API business reported revenues of Rs. 581 Cr. in FY25. EBITDA grew by 39% to Rs. 87 Cr. EBITDA margins improved by 520 basis points to 15% due improved product mix, cost optimisation and higher revenue mix towards CDMO.

Generics

In FY25, the business achieved profitability and delivered EBITDA margins of 3%. The reported revenues for the year stands at Rs. 685 Cr. The success of the overall turnaround strategy was hinged on continuous quality improvement, reduction in overall cost and scaling up profitable products. Going forward, we expect to improve profitability and return to revenue growth.

We plan to launch 6 to 8 products per annum in our US and non-US international markets. We have secured approval of 7 ANDA’s in the last year. We have also acquired 2 ANDAs. In line with our plan, we are ramping up exports to the US markets in a meaningful and gradual manner. We have also started supply of products from our Contract manufacturing partners to the US market in line with our plan.

Proprietary Novel Drugs

The global clinical trials for our lead programs, Phase II trial for JBI -802 for Essential Thrombocythemia (ET) and other Myeloproliferative Neoplasms (MPN) and Phase I trial for JBI -778 for non-small cell lung cancer (NSCLC) and high grade Glioma are actively enrolling patients and progressing in line with our expectations.

Started commercial distribution of PYLARIFY® from PET Radiopharmacies Successfully completed Media Fill on Line 3 in CDMO Sterile Injectables Roorkee facility gradually ramps up generics exports to the US market

1. Normalised PAT is after adjusting for exceptional items

The Board of Jubilant Pharmova Limited met today to approve financial results for the quarter & nine months ended Dec 31, 2024.

Commenting on the Company’s performance, Mr. Shyam S Bhartia, Chairman Jubilant Pharmova and Mr. Hari S Bhartia, Co-Chairman & Non-Executive Director, said, “We are pleased to announce solid revenue growth of 9% YoY on the back of growth across all business segments. EBITDA grew by 11% YoY to Rs. 296 Cr, while reported PAT grew by 52% YoY to Rs. 101 Cr. We repaid debt of USD 125 million in the current financial year including USD 25 million in Jan’25.

In the Radiopharmacy business, we started distribution of Pylarify®, an industry leading prostate cancer diagnostic imaging agent from 2 of our PET radiopharmacies. We completed Media Fills on Line 3 in CDMO Sterile Injectables. The Drug Discovery business is driving increasing revenue from large pharma clients. We have also executed definitive agreements with Pierre Fabre to add strategic capabilities in the area of Biologics and Antibody drug conjugates. In the Generics business, we continue to focus on profitability.”

Q3’FY25 Financial Highlights

In Q3’FY25, Revenue grew by 9% on a YoY basis to Rs. 1,822 Cr. on the back of growth in revenue across all segments. EBITDA grew by 11% on a YoY basis to Rs. 296 Cr. due to improved performance in CDMO Sterile Injectables, CRDMO and Generics. Q3’FY25 normalised PAT increased by 57% on a YoY basis to Rs. 104 Cr. on the back of improved operating performance and reduced finance cost. Net debt / EBITDA improved to 1.4x as on Dec’24 from 2.5x as on Mar’24.

9M’FY25 Financial Highlights

In 9M’FY25, Revenue grew by 7% on YoY basis to Rs. 5,306 Cr. EBITDA grew by 24% on YoY basis to Rs. 873 Cr. due to improved performance in Radiopharma, CDMO Sterile Injectables, CRDMO and Generics. Normalised profit after tax increased by 106% to Rs. 277 Cr. Overall in YTD’FY25, the company has voluntarily prepaid debt of USD 125 million including the latest repayment made in Jan’25 of USD 25 million.

Segmental Business Performance

Radiopharma - Leading Radiopharmaceutical manufacturer & 2nd largest Radiopharmacy network in the US

Radiopharmaceuticals Q3’FY25 revenue grew by 10% YoY to Rs. 265 Cr. Q3’FY25 EBITDA stands at Rs. 125 Cr. with EBITDA margins at 47%. The business continues to maintain a strong position in the high margin SPECT imaging product portfolio. The Ruby-Fill® installations are on track. The dosing for Phase 2 clinical trial for MIBG has been completed. Overall, the business is on track to introduce multiple new products in the medium term.

Radiopharmacy Q3’FY25 revenue grew by 13% YoY to Rs. 576 Cr. Q3’FY25 EBITDA stands at Rs. 5 Cr. In Q3’FY25, the revenues and margins got impacted by industry wide Technetium shortage. During the quarter, our two PET radiopharmacies have started distributing PYLARIFY®, which is an industry leading prostate cancer diagnostic imaging agent.

The proposed investment of US$ 50 million in PET radiopharmacy network is underway. This investment will take the overall radiopharmacy network to fifty two (52) sites, thereby solidly positioning Jubilant Pharmova’s radiopharmacy network as the second largest in the US and shall drive the future business growth.

Allergy Immunotherapy - No. 2 in the US Sub-Cutaneous allergy immunotherapy market

As the sole supplier of Venom in the US, the business is expanding the overall market by increasing customer awareness. In the US Allergenic extracts, the business plans to continue to grow revenues. The business is also working to increase penetration in the outside US markets.

In Q3’FY25, Revenues grew by 7% on YoY basis to Rs. 171 Cr. Q3’FY25 EBITDA stands at Rs. 48 Cr. Q3’FY25 EBITDA margin decreased YoY due to weakness in exports and production challenges for specific SKU’s.  Production challenges have been solved and normalized production has resumed. We anticipate outside US sales to gradually improve. We expect EBITDA margins to revert to normalised levels, starting from Q4’FY25.

CDMO Sterile Injectables

Q3’FY25 revenue is stable YoY at Rs. 306 Cr. and EBITDA grew by 38% YoY to Rs. 51 Cr. Q3’FY25 EBITDA margins increased YoY however decreased QoQ due to semi-annual shutdown. The capacity expansion program in Spokane, Washington, USA is on track. The technology transfer programs on Line 3 are underway and the media fills have been successfully completed on Line 3. The commercial production on line 3 is expected to start in late FY26 or early FY27, post FDA approvals. The Montreal facility restarted operations after successful implementation of corrective and preventive actions.

CRDMO

In Q3’FY25, the Drug Discovery business revenue grew by 32% to Rs. 150 Cr and EBITDA grew by 27% to Rs. 39 Cr. Q3’FY25 revenue increased sharply YoY due to increase in revenue from new contracts from large Pharma customers. Overall, the medium term outlook continues to be positive on the back of the increase in large pharma clients, CDMO revenues and the addition in new capabilities.

The API business reported revenues of Rs. 142 Cr., growth of 3% YoY. Q3’FY25 EBITDA stands at Rs. 20 Cr. EBITDA margins improved by 620 basis points to 14% YoY due to cost optimisation and improvement in product mix.

Generics

After becoming profitable in Q2’FY25, the business profitability improved in Q3’FY25. The success of the overall turnaround strategy was hinged on continuous quality improvement, reduction in overall cost and scaling up profitable products. Q3’FY25 revenues remained stable YoY at Rs. 200 Cr. Reported EBITDA stands at Rs. 30 Cr with EBITDA margins at 15%.

We plan to launch six to eight products per annum in our US and non-US international markets. There are 33 ANDAs in the approval pipeline for the US. We have got approval of 3 ANDA’s in the current financial year. In line with our communication, we are ramping up exports to the US markets in a meaningful and gradual manner. We have also started supply of products from our Contract manufacturing partners to the US market in line with our plan.

Proprietary Novel Drugs

The global clinical trials for our lead programs, Phase II trial for JBI -802 for Essential Thrombocythemia (ET) and other Myeloproliferative Neoplasms (MPN) and Phase I trial for JBI -778 for non-small cell lung cancer (NSCLC) and high grade Glioma are actively enrolling patients and progressing in line with our expectations.

Sustaining growth momentum, EBITDA margin expansion & Net debt/EBITDA improvement

1. Normalised PAT is after adjusting for exceptional items

The Board of Jubilant Pharmova Limited met today to approve financial results for the quarter & half year ended Sep 30, 2024.

Q2’FY25 Financial Highlights

In Q2’FY25, Total income grew by 5% on a YoY basis to Rs. 1,774 Cr. on the back of growth in revenue in Radiopharma and drug discovery services. EBITDA grew by 19% on a YoY basis to Rs. 311 Cr. due to improved performance in CDMO Sterile Injectables, CRDMO and Generics. Generics business became profitable in the current quarter. EBITDA margins improved by 210 basis points on YoY basis to 17.5%. Q2’FY25 normalised PAT increased by 65% on a YoY basis to Rs. 103 Cr. on the back of improved operating performance and reduced finance cost. Net debt / EBITDA improved to 1.5x as on Sep’24 from 2.5x as on Mar’24.

H1’FY25 Financial Highlights

In H1’FY25, total income grew by 7% on YoY basis to Rs. 3,520 Cr. EBITDA grew by 32% on YoY basis to Rs. 577 Cr. due to improved performance in Radiopharma, CDMO Sterile Injectables, CRDMO and Generics. Normalised profit after tax increased by 153% to Rs. 172 Cr.

Signed Strategic partnership with Pierre Fabre

Earlier in this quarter, we announced a strategic partnership with Pierre Fabre, France. Under this partnership, Jubilant Biosys Innovative Research Services Pte Limited, Singapore (‘JBIRSPL’), subsidiary of Jubilant Biosys Limited, a wholly owned subsidiary of the Company would acquire 80% equity capital in Jasmin (new company incorporated in France, as a Société par Actions Simplifiée (SAS), 100% owned by Pierre Fabre). Jasmin shall acquire Pierre Fabre’s R&D Centre (Including R&D Site and R&D activities) at Saint Julien, France, upon closing of the transaction. This strategic partnership will enable Jubilant Biosys to expand its footprint in Europe in areas like Biologics (mAbs) and Antibody Drug Conjugate (ADC), in addition to its existing services including integrated drug discovery services from India.

Segmental Business Performance

Radiopharma - Leading Radiopharmaceutical manufacturer & 2nd largest Radiopharmacy network in the US

Radiopharmaceuticals Q2’FY25 revenue stood at Rs. 251 Cr. with EBITDA margins at 48%. The business continues to maintain a strong position in the high margin SPECT imaging product portfolio. Ruby-Fill® installations are accelerating. The dosing for Phase 2/3 clinical trial for MIBG has been completed. Overall, the business is on track to introduce multiple new products in the medium term.

Radiopharmacy Q2’FY25 revenue grew by 16% YoY to Rs. 568 Cr. and EBITDA remained stable (YoY) at Rs. 6 Cr. The proposed investment of US$ 50 million in PET radiopharmacy network is underway. This investment will take the overall radiopharmacy network to fifty two (52) sites, thereby solidly positioning Jubilant Pharmova’s radiopharmacy network as the second largest in the US and shall drive the future business growth.

Allergy Immunotherapy - No. 2 in the US Sub-Cutaneous allergy immunotherapy market

Allergy Immunotherapy business reported Q2’FY25 revenue at Rs. 170 Cr. and EBITDA at Rs. 46 Cr. As the sole supplier of Venom in the US, the business is expanding the overall market by increasing customer awareness. In the US Allergenic extracts, the business continues to maintain market share. The revenue was lower YoY due to a delay in product launches in the new (outside US) markets by our partners. The EBITDA margins came lower in the quarter on YoY basis due to lower revenue from the outside US markets and lower production. The margin is expected to normalise in the second half of the financial year.

CDMO Sterile Injectables

Q2’FY25 revenue remained stable at Rs. 302 Cr. and EBITDA grew by 59% YoY to Rs. 89 Cr. The capacity expansion program in Spokane, Washington, USA is on track. The technology transfer programs on Line 3 are underway. The commercial production shall start in FY26 or FY27, post FDA approvals.

CRDMO

In Q2’FY25, the Drug Discovery business revenue grew by 32% to Rs. 151 Cr and EBITDA grew by 39% to Rs. 36 Cr. Q2’FY25 revenue increased sharply YoY due to increase in revenue from new contracts from large Pharma customers and incremental revenues in CDMO business. Q2’FY25 EBITDA margins expanded YoY due to sharp revenue growth. The business onboarded one large pharma company as its client in Q2’FY25. Overall, the medium term outlook continues to be positive on the back of the increase in large pharma clients, CDMO revenues and the addition in new capabilities.

The API business reported revenues of Rs. 127 Cr. and EBITDA of Rs. 12 Cr. for Q2’FY25. Revenues decreased YoY due to focus on selling profitable products. EBITDA margins improved YoY due to cost optimisation efforts.

Generics

The business became profitable in Q2’FY25, sooner than our expectations. The success of the overall turnaround strategy was hinged on continuous quality improvement, reduction in overall cost and scaling up profitable products. Our large markets, US and non-US international business, both are now profitable. Q2’FY25 revenues remained stable YoY at Rs. 173 Cr. Reported EBITDA stands at Rs. 21 Cr. and with margins at 12%.

We plan to launch six to eight products per annum in our US and non-US international markets. We also plan to start the supply of approved products from Roorkee facility to the US market in H2’FY25. There are 35 ANDAs in the approval pipeline for the US. In our last update, we had communicated that following the status change of the solid dosage formulation facility at Roorkee, the exports to the US markets are expected to increase in a meaningful and gradual manner.

Proprietary Novel Drugs

We are happy to announce the dosing of first patients in global clinical trials involving both of our lead programs, Phase II trial for JBI -802 for Essential Thrombocythemia (ET) and other Myeloproliferative Neoplasms (MPN) and Phase I trial for JBI -778 for non-small cell lung cancer (NSCLC) and high grade Glioma.

• JBI-802 is a first-in-class, orally administered, inhibitor of CoREST complex
• JBI-778 is a potential best-in-class, orally administered, brain penetrant inhibitor of PRMT5

Yardley, Pennsylvania, Oct 25, 2024 – Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule precision therapeutics to address unmet medical needs in oncology and autoimmune diseases today announced the dosing of first patients in global clinical trials involving two pipeline programs: Phase I/II clinical trial of JBI-802 in heme-oncology and Phase I clinical trial for JBI-778 in solid tumors.

“We are excited to take this significant step forward in our mission to transform the lives of patients through the development of easy to administer precision oral medicines with enhanced safety and therapeutic efficacy,” saidHari S Bhartia, Chairman, Jubilant Therapeutics Inc.

JBI-802 is a first-in-class, orally administered, small-molecule dual inhibitor of LSD1 (Lysine-specific histone demethylase 1A) and HDAC6 (Histone deacetylase 6) within the CoREST (Co-repressor of Repressor Element-1 Silencing Transcription) complex. In the earlier Phase I study conducted in advanced solid tumor patients, JBI-802 showed a dose-proportional increase in exposure across cohorts and a strong correlation between exposure and the on-target effect of platelet decrease. There were no reports of Dysgeusia and Anemia, typical adverse events seen with LSD1only inhibitors. The Phase I trial also showed anti-tumor activity in Non-Small Cell Lung Cancer (NSCLC) patients including a confirmed partial response. Overall, the study results provided human proof-of-principle for expanding the development of JBI-802 in Essential Thrombocythemia and Myelodysplastic Syndrome/Myeloproliferative Neoplasms (MDS/MPN) with thrombocytosis.

Essential Thrombocythemia is a chronic disease of excessive platelets with over 100,000 patients in the United States for whom the primary treatment is hydroxyurea, a therapy that poses sever limitations for patients in terms of both safety and efficacy.

The second clinical trial is to assess both safety and the recommended Phase II dose for JBI-778, an oral brain-penetrant inhibitor of PRMT5 (Protein arginine N-methyltransferase 5) in mEGFR Tyrosine Kinase Inhibitor (TKI) resistant NSCLC, IDH+ high-grade glioma (HGG) and Adenoid Cystic Carcinoma (ACC).

PRMT5, although a proven pathway for multiple cancers, has produced mixed results in terms of drug development due to safety concerns surrounding SAM competitive approach to PRMT5 inhibition and patient segment limitations of MTAP null tumor-focused approach PRMT5 inhibition. JBI-778 is a unique substrate competitive brain penetrant PRMT5 inhibitor that has shown no adverse effects in preclinical setting and can address both MTAP null and wild type tumors as well as brain tumors, catering to larger patient segment including those with brain metastases.  
“The two most advanced novel drug candidates at Jubilant Therapeutics Inc. were discovered in-house using our TIBEO [Therapeutic Index and Brain Exposure Optimization] Discovery Engine. It is our unique approach of structure-based drug design to generate novel pharmacophores with improved therapeutic index compared to existing agents. We are excited to advance both JBI-802 and JBI-778 in genetically-defined subsets of patients with select hematological and solid tumor indications with high unmet medical needs. Initial clinical data are expected to read out in 2025”, said Syed Kazmi, Chief Executive officer, Jubilant Therapeutics Inc.

About JBI-802

JBI-802 is novel, oral, potent and selective dual inhibitor of two epigenetic targets of the CoREST complex: LSD1 and HDAC6. It targets stem cell modulation by inhibiting LSD1 and modulates immune suppression with isoform selective HDAC6 inhibition. Preclinical research has demonstrated its synergistic anti-tumor activity, which is superior compared to either target alone and with a favorable safety profile. JBI-802 is under evaluation in both hematological cancers such as acute myeloid leukemia, myelodysplastic syndrome and other myeloproliferative cancers as well as solid tumors, such as non-small cell lung cancer and small cell lung cancer.

About JBI-778

JBI-778 is novel, oral, potent and brain penetrant inhibitor of PRMT5. JBI-778 targets the substrate site and stabilizes SAM bound to PRMT5, providing high biological selectivity and has shown a superior safety profile as seen in animals. Preclinical research has demonstrated significant activity in Tyrokinase-Inhibitor resistant cell lines, brain tumor and NSCLC. JBI-778 is under evaluation in solid tumors such as NSCLC, High Grade Glioma and Adenoid Cystic Carcinoma.

Noida, October 09, 2024: Jubilant Biosys Innovative Research Services Pte Limited, Singapore (‘JBIRSPL’), subsidiary of Jubilant Biosys Limited, a wholly owned subsidiary of Jubilant Pharmova Limited and Pierre Fabre SA are entering in a strategic partnership. Pursuant to this, JBIRSPL would acquire 80% equity capital in Jasmin (new company incorporated in France, as a Société par Actions Simplifiée (SAS), 100% owned by Pierre Fabre). Jasmin shall acquire Pierre Fabre’s R&D Centre (Including R&D Site and R&D activities) at Saint Julien, France upon closing of the transaction.

This strategic partnership will enable Jubilant Biosys Limited to expand its footprint in Europe in areas like Biologics (mAbs) and Antibody Drug Conjugate (ADC), in addition to its existing services including integrated drug discovery services from India.

Speaking on the announcement, Giuliano Perfetti, CEO & Managing Director of Jubilant Biosys Limited said, “We are excited to embark on this new strategic partnership with Pierre Fabre. The facility in Saint Julien will serve as our European Centre of Excellence for Biologics and ADCs, located in the heart of Europe. This will enhance our footprint and collaboration with both biotech and large pharma companies in Europe and the USA. By combining the scientific expertise in Biologics and ADCs at our Saint Julien site with the capabilities of 1,200 scientists at our Centres of Excellence for Drug Discovery, Chemistry and CDMO in India, we can develop a unique delivery model tailored to our customers' needs, driving our company’s growth. With this strategic move, Jubilant Biosys continues to strengthen its position as a preferred “CRDMO Partner in Science,” committed to delivering innovative solutions to our customers.”